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- Document 0717
- DOCN M9460717
- TI Sequential changes in vital signs and acid-base and blood-gas profiles
- in Pneumocystis carinii pneumonitis in children with cancer. Basis for a
- scoring system to identify patients who will require ventilatory
- support.
- DT 9408
- AU Sanyal SK; Chebib FS; Gilbert JR; Hughes WT; Department of Pediatrics,
- King Faisal University, Dammam, Saudi; Arabia.
- SO Am J Respir Crit Care Med. 1994 May;149(5):1092-8. Unique Identifier :
- AIDSLINE MED/94228045
- AB Early reliable identification of patients with Pneumocystis carinii
- pneumonia (PCP) who will require ventilatory support would be desirable.
- To develop a predictive system to meet this need, we studied,
- prospectively, the sequential alterations in vital signs and acid-base
- and blood-gas profiles associated with this disease in 55 children with
- cancer, 29 of whom did not require ventilatory support (Group I) and 26
- who did (Group II). None of the patients had acquired immunodeficiency
- syndrome (AIDS). On admission to the hospital the only feature that
- distinguished patients in Group I from those in Group II was the mean
- (+/- SD) respiratory rate (38.7 +/- 2.1 versus 49.1 +/- 3.5 breaths/min,
- p < 0.02). By 12 h after admission there was a significant difference in
- the partial pressure of oxygen (PaO2) between Groups I and II (75.1 +/-
- 3.2 mg Hg versus 65.4 +/- 3.1 mm Hg, p < 0.05), and also in the two
- groups' inspired fraction of oxygen (FIO2; 24.9 +/- 0.54% versus 29.6
- +/- 1.6%, p < 0.01). Both alterations, as well as tachypnea, persisted
- for the remainder of the study period. The maximum FIO2 did not exceed
- 45% in Group I, and by 60 h after admission to the hospital, all
- patients in this group had persistent increases in PaO2 that exceeded 80
- mm Hg, permitting decreases in FIO2 to that of room air. In Group II,
- hypoxemia was refractory despite an increase in FIO2 to 50%, at which
- point ventilatory support was begun (at a mean of 81.1 +/- 32.3 h after
- admission).(ABSTRACT TRUNCATED AT 250 WORDS)
- DE Acid-Base Equilibrium Adolescence Body Temperature Carbon
- Dioxide/BLOOD Child Child, Preschool Female Heart Rate Human
- Immunocompromised Host Infant Male
- Neoplasms/*COMPLICATIONS/IMMUNOLOGY Oxygen/BLOOD Pneumonia,
- Pneumocystis carinii/BLOOD/COMPLICATIONS/ *PHYSIOPATHOLOGY/THERAPY
- Prospective Studies Respiration *Respiration, Artificial Risk Factors
- Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
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-